Structural highlights
Function
ROK_BACSU Repressor of comK, the master regulator of competence development (PubMed:11849533). Overexpression seems to be lethal (PubMed:11849533). Represses at least 20 genes that specify membrane-localized and secreted proteins, including some that encode products with antibiotic activity (PubMed:15743949). Binds to many AT-rich sites in the chromosome, many of which are known or thought to derive from horizontal gene transfer; helps keep mobile element ICEBs1 quiescent in the genome (PubMed:21085634). Binds to its own promoter and is thus probably autoregulatory (PubMed:21085634).[1] [2] [3]
References
- ↑ Hoa TT, Tortosa P, Albano M, Dubnau D. Rok (YkuW) regulates genetic competence in Bacillus subtilis by directly repressing comK. Mol Microbiol. 2002 Jan;43(1):15-26. PMID:11849533 doi:10.1046/j.1365-2958.2002.02727.x
- ↑ Albano M, Smits WK, Ho LT, Kraigher B, Mandic-Mulec I, Kuipers OP, Dubnau D. The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions. J Bacteriol. 2005 Mar;187(6):2010-9. PMID:15743949 doi:10.1128/JB.187.6.2010-2019.2005
- ↑ Smits WK, Grossman AD. The transcriptional regulator Rok binds A+T-rich DNA and is involved in repression of a mobile genetic element in Bacillus subtilis. PLoS Genet. 2010 Nov 11;6(11):e1001207. PMID:21085634 doi:10.1371/journal.pgen.1001207
