Structural highlights
Function
DCXH_TOXGV Specifically required in the formation and maintenance of the conoid fibers; the conoid is a component of the cytoskeletal apical complex, which is composed of a left-handed spiral of 14 fibers made from a nontubular tubulin polymer (PubMed:27932494). Promotes the organization, curvature, and stability of the conoid fibers, and probably bridges other conoid components to the tubulin core (PubMed:27932494, PubMed:32111164).[1] [2]
References
- ↑ Nagayasu E, Hwang YC, Liu J, Murray JM, Hu K. Loss of a doublecortin (DCX)-domain protein causes structural defects in a tubulin-based organelle of Toxoplasma gondii and impairs host-cell invasion. Mol Biol Cell. 2017 Feb 1;28(3):411-428. PMID:27932494 doi:10.1091/mbc.E16-08-0587
- ↑ Leung JM, Nagayasu E, Hwang YC, Liu J, Pierce PG, Phan IQ, Prentice RA, Murray JM, Hu K. A doublecortin-domain protein of Toxoplasma and its orthologues bind to and modify the structure and organization of tubulin polymers. BMC Mol Cell Biol. 2020 Feb 28;21(1):8. doi: 10.1186/s12860-020-0249-5. PMID:32111164 doi:http://dx.doi.org/10.1186/s12860-020-0249-5
