6bhx

Structural highlights

Function

SSBA_BACSU Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism (PubMed:21170359). Has a 20-fold higher affinity for ssDNA than SsbB; SsbA and DprA activate the homologuos DNA strand exchange function of RecA-ATP (PubMed:25138221).^{[1] [2]}

See Also

• Single-stranded DNA-binding protein 3D structures

References

1. ↑ Yadav T, Carrasco B, Serrano E, Alonso JC. Roles of Bacillus subtilis DprA and SsbA in RecA-mediated genetic recombination. J Biol Chem. 2014 Oct 3;289(40):27640-52. doi: 10.1074/jbc.M114.577924. Epub 2014, Aug 19. PMID:25138221 doi:http://dx.doi.org/10.1074/jbc.M114.577924
2. ↑ Costes A, Lecointe F, McGovern S, Quevillon-Cheruel S, Polard P. The C-terminal domain of the bacterial SSB protein acts as a DNA maintenance hub at active chromosome replication forks. PLoS Genet. 2010 Dec 9;6(12):e1001238. doi: 10.1371/journal.pgen.1001238. PMID:21170359 doi:http://dx.doi.org/10.1371/journal.pgen.1001238