6cjn

Structural highlights

Function

CFI1_MEDSA Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones. Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin.^{[1] [2] [3]}

References

1. ↑ Jez JM, Bowman ME, Dixon RA, Noel JP. Structure and mechanism of the evolutionarily unique plant enzyme chalcone isomerase. Nat Struct Biol. 2000 Sep;7(9):786-91. PMID:10966651 doi:10.1038/79025
2. ↑ Jez JM, Bowman ME, Noel JP. Role of hydrogen bonds in the reaction mechanism of chalcone isomerase. Biochemistry. 2002 Apr 23;41(16):5168-76. PMID:11955065
3. ↑ Jez JM, Noel JP. Reaction mechanism of chalcone isomerase. pH dependence, diffusion control, and product binding differences. J Biol Chem. 2002 Jan 11;277(2):1361-9. Epub 2001 Nov 6. PMID:11698411 doi:10.1074/jbc.M109224200