6cpj

From Proteopedia

Solution structure of SH3 domain from Shank2

Structural highlights

6cpj is a 1 chain structure with sequence from Rattus norvegicus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SHAN2_RAT Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.^[1]

References

↑ Lim S, Naisbitt S, Yoon J, Hwang JI, Suh PG, Sheng M, Kim E. Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development. J Biol Chem. 1999 Oct 8;274(41):29510-8. PMID:10506216

1 Structural highlights
2 Function
3 See Also
4 References

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PDB ID 6cpj

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Categories: Large Structures | Rattus norvegicus | Ishida H | Vogel HJ

6cpj

From Proteopedia

Solution structure of SH3 domain from Shank2

Structural highlights

Function

See Also

References

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