Structural highlights
6f34 is a 2 chain structure with sequence from Ecoli and Geoka. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , |
| Related: | 5oqt |
| Gene: | GK0930, ApcT (GEOKA), yneM, b4599, JW1527.1 (ECOLI) |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Publication Abstract from PubMed
Amino acids play essential roles in cell biology as regulators of metabolic pathways. Arginine in particular is a major signalling molecule inside the cell, being a precursor for both l-ornithine and nitric oxide (NO) synthesis and a key regulator of the mTORC1 pathway. In mammals, cellular arginine availability is determined by members of the solute carrier (SLC) 7 family of cationic amino acid transporters. Whereas CAT-1 functions to supply cationic amino acids for cellular metabolism, CAT-2A and -2B are required for macrophage activation and play important roles in regulating inflammation. Here, we present the crystal structure of a close homologue of the mammalian CAT transporters that reveals how these proteins specifically recognise arginine. Our structural and functional data provide a model for cationic amino acid transport in mammalian cells and reveals mechanistic insights into proton-coupled, sodium-independent amino acid transport in the wider APC superfamily.
Structural basis for amino acid transport by the CAT family of SLC7 transporters.,Jungnickel KEJ, Parker JL, Newstead S Nat Commun. 2018 Feb 7;9(1):550. doi: 10.1038/s41467-018-03066-6. PMID:29416041[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Jungnickel KEJ, Parker JL, Newstead S. Structural basis for amino acid transport by the CAT family of SLC7 transporters. Nat Commun. 2018 Feb 7;9(1):550. doi: 10.1038/s41467-018-03066-6. PMID:29416041 doi:http://dx.doi.org/10.1038/s41467-018-03066-6
