Structural highlights
Publication Abstract from PubMed
Four-way junctions (4WJs) are supramolecular DNA assemblies comprising four interacting DNA strands that in biology are involved in DNA-damage repair. In this study, a new mononuclear platinum(II) complex 1 was prepared that is capable of driving the crystallization of the DNA oligomer 5'-d(CGTACG)-3' specifically into a 4WJ-like motif. In the crystal structure of the 1-CGTACG adduct, the distorted-square-planar platinum complex binds to the core of the 4WJ-like motif through pi-pi stacking and hydrogen bonding, without forming any platinum-nitrogen coordination bonds. Our observations suggest that the specific molecular properties of the metal complex are crucially responsible for triggering the selective assembly of this peculiar DNA superstructure.
Induction of a Four-Way Junction Structure in the DNA Palindromic Hexanucleotide 5'-d(CGTACG)-3' by a Mononuclear Platinum Complex.,van Rixel VHS, Busemann A, Wissingh MF, Hopkins SL, Siewert B, van de Griend C, Siegler MA, Marzo T, Papi F, Ferraroni M, Gratteri P, Bazzicalupi C, Messori L, Bonnet S Angew Chem Int Ed Engl. 2019 May 2. doi: 10.1002/anie.201814532. PMID:31046177[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ van Rixel VHS, Busemann A, Wissingh MF, Hopkins SL, Siewert B, van de Griend C, Siegler MA, Marzo T, Papi F, Ferraroni M, Gratteri P, Bazzicalupi C, Messori L, Bonnet S. Induction of a Four-Way Junction Structure in the DNA Palindromic Hexanucleotide 5'-d(CGTACG)-3' by a Mononuclear Platinum Complex. Angew Chem Int Ed Engl. 2019 May 2. doi: 10.1002/anie.201814532. PMID:31046177 doi:http://dx.doi.org/10.1002/anie.201814532
