Structural highlights
Function
KA120_YEAST Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, RAN-dependent mechanism. Required for nuclear import of Ho endonuclease and RFP1, and involved in rRNA-processing and assembly or export of 60S ribosomal subunits.[1] [2] [3] [4]
References
- ↑ Stage-Zimmermann T, Schmidt U, Silver PA. Factors affecting nuclear export of the 60S ribosomal subunit in vivo. Mol Biol Cell. 2000 Nov;11(11):3777-89. PMID:11071906
- ↑ Zettel MF, Garza LR, Cass AM, Myhre RA, Haizlip LA, Osadebe SN, Sudimack DW, Pathak R, Stone TL, Polymenis M. The budding index of Saccharomyces cerevisiae deletion strains identifies genes important for cell cycle progression. FEMS Microbiol Lett. 2003 Jun 27;223(2):253-8. PMID:12829295 doi:10.1016/S0378-1097(03)00384-7
- ↑ Bakhrat A, Baranes K, Krichevsky O, Rom I, Schlenstedt G, Pietrokovski S, Raveh D. Nuclear import of ho endonuclease utilizes two nuclear localization signals and four importins of the ribosomal import system. J Biol Chem. 2006 May 5;281(18):12218-26. PMID:16507575 doi:10.1074/jbc.M600238200
- ↑ Caesar S, Greiner M, Schlenstedt G. Kap120 functions as a nuclear import receptor for ribosome assembly factor Rpf1 in yeast. Mol Cell Biol. 2006 Apr;26(8):3170-80. PMID:16581791 doi:10.1128/MCB.26.8.3170-3180.2006
