Structural highlights
Publication Abstract from PubMed
In human and other mammalian cells, transport of L-lactate across plasma membranes is mainly catalyzed by monocarboxylate transporters (MCTs) of the SLC16 solute carrier family. MCTs play an important role in cancer metabolism and are promising targets for tumor treatment. Here, we report the crystal structures of an SLC16 family homologue with two different bound ligands at 2.54 and 2.69 A resolution. The structures show the transporter in the pharmacologically relevant outward-open conformation. Structural information together with a detailed structure-based analysis of the transport function provide important insights into the molecular working mechanisms of ligand binding and L-lactate transport.
Mechanistic basis of L-lactate transport in the SLC16 solute carrier family.,Bosshart PD, Kalbermatter D, Bonetti S, Fotiadis D Nat Commun. 2019 Jun 14;10(1):2649. doi: 10.1038/s41467-019-10566-6. PMID:31201333[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Bosshart PD, Kalbermatter D, Bonetti S, Fotiadis D. Mechanistic basis of L-lactate transport in the SLC16 solute carrier family. Nat Commun. 2019 Jun 14;10(1):2649. doi: 10.1038/s41467-019-10566-6. PMID:31201333 doi:http://dx.doi.org/10.1038/s41467-019-10566-6
