6iqk

Structural highlights

Function

PRF3_ARATH Binds to actin monomers and regulates the organization of the actin cytoskeleton (PubMed:23052593, PubMed:29861135). Can increase the critical concentration (Cc) of actin assembly in vitro (PubMed:23052593). Acts as downstream effector of the hydrogen sulfide signaling to regulate the assembly and depolymerization of F-actin (PubMed:25652660). At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (Probable). Binding to the poly-proline motif of formin induces oligomerization of PRF3 (PubMed:29861135). PRF3 oligomers inhibit formin-mediated actin assembly to modulate plant immunity triggered by pathogen-associated molecular patterns (PAMPs) (PubMed:29861135).^{[1] [2] [3] [4]}

See Also

• Profilin 3D Structures

References

1. ↑ Fan T, Zhai H, Shi W, Wang J, Jia H, Xiang Y, An L. Overexpression of profilin 3 affects cell elongation and F-actin organization in Arabidopsis thaliana. Plant Cell Rep. 2013 Jan;32(1):149-60. PMID:23052593 doi:10.1007/s00299-012-1349-2
2. ↑ Jia H, Hu Y, Fan T, Li J. Hydrogen sulfide modulates actin-dependent auxin transport via regulating ABPs results in changing of root development in Arabidopsis. Sci Rep. 2015 Feb 5;5:8251. PMID:25652660 doi:10.1038/srep08251
3. ↑ Sun H, Qiao Z, Chua KP, Tursic A, Liu X, Gao YG, Mu Y, Hou X, Miao Y. Profilin Negatively Regulates Formin-Mediated Actin Assembly to Modulate PAMP-Triggered Plant Immunity. Curr Biol. 2018 Jun 18;28(12):1882-1895.e7. PMID:29861135 doi:10.1016/j.cub.2018.04.045
4. ↑ Sun H, Qiao Z, Chua KP, Tursic A, Liu X, Gao YG, Mu Y, Hou X, Miao Y. Profilin Negatively Regulates Formin-Mediated Actin Assembly to Modulate PAMP-Triggered Plant Immunity. Curr Biol. 2018 Jun 18;28(12):1882-1895.e7. PMID:29861135 doi:10.1016/j.cub.2018.04.045