Structural highlights
Function
Q6VMI4_STRAM
Publication Abstract from PubMed
AlpK is an essential monooxygenase involved in the biosynthesis of kinamycin. It catalyzes the C5-hyfroxylattion of the crucial benzo[b]-fluorence intermediate in kinamycin synthesis. However, the structure and mechanism of AlpK is unclear. Here, we report the first structure of AlpK in complex with FAD. Our structure sheds light on the catalytic mechanism of AlpK.
Crystal structure of AlpK: An essential monooxygenase involved in the biosynthesis of kinamycin.,Wang W, Li J, Li H, Fan K, Liu Y Biochem Biophys Res Commun. 2019 Mar 19;510(4):601-605. doi:, 10.1016/j.bbrc.2019.01.077. Epub 2019 Feb 7. PMID:30739782[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Wang W, Li J, Li H, Fan K, Liu Y. Crystal structure of AlpK: An essential monooxygenase involved in the biosynthesis of kinamycin. Biochem Biophys Res Commun. 2019 Mar 19;510(4):601-605. doi:, 10.1016/j.bbrc.2019.01.077. Epub 2019 Feb 7. PMID:30739782 doi:http://dx.doi.org/10.1016/j.bbrc.2019.01.077
