6j5w

Structural highlights

Function

ZRK1_ARATH Serine/threonine-protein kinase that confers a broad-spectrum quantitative disease resistance (QDR) to the pathogenic biotrophic bacteria Xanthomonas campestris (e.g. pv. campestris (Xcc), pv. raphani, pv. armoriaceae and pv. incanae) by restricting bacterial spread to the vascular system from the infection site; X.campestris causes black rot disease in crops (PubMed:24068949, PubMed:26355215, PubMed:30948526). Seems to not have any kinase activity (PubMed:24068949).^{[1] [2] [3]}

References

1. ↑ Huard-Chauveau C, Perchepied L, Debieu M, Rivas S, Kroj T, Kars I, Bergelson J, Roux F, Roby D. An atypical kinase under balancing selection confers broad-spectrum disease resistance in Arabidopsis. PLoS Genet. 2013;9(9):e1003766. PMID:24068949 doi:10.1371/journal.pgen.1003766
2. ↑ Wang G, Roux B, Feng F, Guy E, Li L, Li N, Zhang X, Lautier M, Jardinaud MF, Chabannes M, Arlat M, Chen S, He C, Noël LD, Zhou JM. The Decoy Substrate of a Pathogen Effector and a Pseudokinase Specify Pathogen-Induced Modified-Self Recognition and Immunity in Plants. Cell Host Microbe. 2015 Sep 9;18(3):285-95. PMID:26355215 doi:10.1016/j.chom.2015.08.004
3. ↑ Wang J, Wang J, Hu M, Wu S, Qi J, Wang G, Han Z, Qi Y, Gao N, Wang HW, Zhou JM, Chai J. Ligand-triggered allosteric ADP release primes a plant NLR complex. Science. 2019 Apr 5;364(6435). pii: 364/6435/eaav5868. doi:, 10.1126/science.aav5868. PMID:30948526 doi:http://dx.doi.org/10.1126/science.aav5868