6k85

Structural highlights

Function

RGLG1_ARATH E3 ubiquitin-protein ligase that mediates the formation of 'Lys-63'-linked ubiquitin chains. Regulates apical dominance by acting on the auxin transport proteins abundance (PubMed:17586653). Together with RGLG5, mediates the ubiquitination and subsequent proteasomal degradation of the target protein PP2CA. Functions as positive regulator of abscisic acid (ABA) signaling through ABA-dependent degradation of PP2CA, a major inhibitor of ABA signaling (PubMed:27577789). Acts as a negative regulator of drought stress response (PubMed:22095047).^{[1] [2] [3]}

See Also

• Ubiquitin protein ligase 3D structures

References

1. ↑ Yin XJ, Volk S, Ljung K, Mehlmer N, Dolezal K, Ditengou F, Hanano S, Davis SJ, Schmelzer E, Sandberg G, Teige M, Palme K, Pickart C, Bachmair A. Ubiquitin lysine 63 chain forming ligases regulate apical dominance in Arabidopsis. Plant Cell. 2007 Jun;19(6):1898-911. PMID:17586653 doi:10.1105/tpc.107.052035
2. ↑ Cheng MC, Hsieh EJ, Chen JH, Chen HY, Lin TP. Arabidopsis RGLG2, functioning as a RING E3 ligase, interacts with AtERF53 and negatively regulates the plant drought stress response. Plant Physiol. 2012 Jan;158(1):363-75. PMID:22095047 doi:10.1104/pp.111.189738
3. ↑ Wu Q, Zhang X, Peirats-Llobet M, Belda-Palazon B, Wang X, Cui S, Yu X, Rodriguez PL, An C. Ubiquitin Ligases RGLG1 and RGLG5 Regulate Abscisic Acid Signaling by Controlling the Turnover of Phosphatase PP2CA. Plant Cell. 2016 Sep;28(9):2178-2196. PMID:27577789 doi:10.1105/tpc.16.00364