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Publication Abstract from PubMed

Cyclobutane pyrimidine dimers (CPD), as a common DNA damage caused by UV radiation, often lead to skin cancer. Here, we identified a photolyase from the alga Arthrospira platensis (designated as Ap-phr), which has been regarded as a safe organism for humans for centuries, that can efficiently repair CPD lesions in ssDNA and dsDNA in vitro. The 1.6 A resolution crystal structure of Ap-phr revealed that it possesses a unique methenyltetrahydrofolate chromophore-binding pattern with high energy transfer efficiency. Our study of Ap-phr highlights its potential use in cosmetic, industrial and aesthetic medicine applications.

A newly identified photolyase from Arthrospira platensis possesses a unique methenyltetrahydrofolate chromophore-binding pattern.,Yan H, Zhu K, Teng M, Li X FEBS Lett. 2020 Feb;594(4):740-750. doi: 10.1002/1873-3468.13657. Epub 2019 Nov, 24. PMID:31675429^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.