6ku9

Structural highlights

Function

CAPSH_ASFB7 Capsid protein that self-assembles to form the pseudo-hexameric capsomers of the icosahedral capsid (PubMed:31624094). The capsid is constructed of 2760 pseudo-hexameric capsomers and 12 pentameric capsomers, with a T=277 symmetry, about 200 nm in diameter (PubMed:31624094). The capsid encapsulates the DNA-containing nucleoid, the core shell and the inner membrane (PubMed:9580160). Plays an essential role in virion assembly (PubMed:9580160). Involved in virus attachment to the host cell (PubMed:8764090).^{[1] [2] [3]}

References

1. ↑ Wang N, Zhao D, Wang J, Zhang Y, Wang M, Gao Y, Li F, Wang J, Bu Z, Rao Z, Wang X. Architecture of African swine fever virus and implications for viral assembly. Science. 2019 Nov 1;366(6465):640-644. PMID:31624094 doi:10.1126/science.aaz1439
2. ↑ Gómez-Puertas P, Rodríguez F, Oviedo JM, Ramiro-Ibáñez F, Ruiz-Gonzalvo F, Alonso C, Escribano JM. Neutralizing antibodies to different proteins of African swine fever virus inhibit both virus attachment and internalization. J Virol. 1996 Aug;70(8):5689-94. PMID:8764090 doi:10.1128/JVI.70.8.5689-5694.1996
3. ↑ García-Escudero R, Andrés G, Almazán F, Viñuela E. Inducible gene expression from African swine fever virus recombinants: analysis of the major capsid protein p72. J Virol. 1998 Apr;72(4):3185-95. PMID:9580160 doi:10.1128/JVI.72.4.3185-3195.1998