Structural highlights
Function
HPTS_STAA8 Member of the two-component regulatory system HptS/HptR that regulates genes involved in hexose phosphate transport system in response to changes in extracellular phosphate sources (PubMed:25644013). May act as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of HptS. In turn, HptS antagonizes CcpA-dependent transcription of a subset of CcpA-regulated genes involved in antibiotic susceptibility (PubMed:30540769).[1] [2]
References
- ↑ Park JY, Kim JW, Moon BY, Lee J, Fortin YJ, Austin FW, Yang SJ, Seo KS. Characterization of a novel two-component regulatory system, HptRS, the regulator for the hexose phosphate transport system in Staphylococcus aureus. Infect Immun. 2015 Apr;83(4):1620-8. PMID:25644013 doi:10.1128/IAI.03109-14
- ↑ Reed JM, Olson S, Brees DF, Griffin CE, Grove RA, Davis PJ, Kachman SD, Adamec J, Somerville GA. Coordinated regulation of transcription by CcpA and the Staphylococcus aureus two-component system HptRS. PLoS One. 2018 Dec 12;13(12):e0207161. PMID:30540769 doi:10.1371/journal.pone.0207161
