Structural highlights
Function
TRM1_HHV11 Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM2 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM1 carries an endonuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.[HAMAP-Rule:MF_04014][1] [2]
See Also
References
- ↑ Wills E, Scholtes L, Baines JD. Herpes simplex virus 1 DNA packaging proteins encoded by UL6, UL15, UL17, UL28, and UL33 are located on the external surface of the viral capsid. J Virol. 2006 Nov;80(21):10894-9. PMID:16920825 doi:10.1128/JVI.01364-06
- ↑ Taus NS, Baines JD. Herpes simplex virus 1 DNA cleavage/packaging: the UL28 gene encodes a minor component of B capsids. Virology. 1998 Dec 20;252(2):443-9. PMID:9878624 doi:10.1006/viro.1998.9475
