Structural highlights
Function
MAVE_LEGPH Virulence effector that is indispensable for endoplasmic reticulum (ER)-mediated remodeling of the Legionella pneumophila-containing vacuole (LCV) and lysosomal evasion (PubMed:33563829). Essential for intracellular replication in human monocyte-derived macrophages (hMDMs) and amoebae, as well as for intrapulmonary proliferation in mice (PubMed:33563829).[1]
References
- ↑ Vaughn B, Voth K, Price CT, Jones S, Ozanic M, Santic M, Cygler M, Abu Kwaik Y. An Indispensable Role for the MavE Effector of Legionella pneumophila in Lysosomal Evasion. mBio. 2021 Feb 9;12(1):e03458-20. PMID:33563829 doi:10.1128/mBio.03458-20
