Structural highlights
Publication Abstract from PubMed
We report the heterologous expression, structure, and antimicrobial activity of a lasso peptide, ubonodin, encoded in the genome of Burkholderia ubonensis . The topology of ubonodin is unprecedented amongst lasso peptides with 18 of its 28 amino acids found in the mechanically-bonded loop segment. Ubonodin inhibits RNA polymerase in vitro and has potent antimicrobial activity against several pathogenic members of the Burkholderia genus, most notably B. cepacia and B. multivorans , causative agents of lung infections in cystic fibrosis patients.
Discovery of ubonodin, an antimicrobial lasso peptide active against members of the Burkholderia cepacia complex.,Cheung-Lee WL, Parry M, Zong C, Jaramillo Cartagena A, Darst S, Connell N, Russo R, Link AJ Chembiochem. 2019 Nov 25. doi: 10.1002/cbic.201900707. PMID:31765515[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Cheung-Lee WL, Parry M, Zong C, Jaramillo Cartagena A, Darst S, Connell N, Russo R, Link AJ. Discovery of ubonodin, an antimicrobial lasso peptide active against members of the Burkholderia cepacia complex. Chembiochem. 2019 Nov 25. doi: 10.1002/cbic.201900707. PMID:31765515 doi:http://dx.doi.org/10.1002/cbic.201900707