Structural highlights
Function
IYD_THENN Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (PubMed:34748729). Activity towards 2-iodophenol is weak (PubMed:34748729).[1]
References
- ↑ Sun Z, Xu B, Spisak S, Kavran JM, Rokita SE. The minimal structure for iodotyrosine deiodinase function is defined by an outlier protein from the thermophilic bacterium Thermotoga neapolitana. J Biol Chem. 2021 Dec;297(6):101385. doi: 10.1016/j.jbc.2021.101385. Epub 2021, Nov 6. PMID:34748729 doi:http://dx.doi.org/10.1016/j.jbc.2021.101385
