6rz0

Structural highlights

Function

GLO2_ECOLI Type II glyoxalase that catalyzes the hydrolysis of (R)-S-lactoylglutathione to (R)-lactate and glutathione (PubMed:25670698, PubMed:17196158). Is more efficient than the isozyme GloC, and plays a major contribution to methylglyoxal (MG) detoxification in E.coli (PubMed:25670698). The two isoenzymes have additive effects and ensure maximal MG degradation (PubMed:25670698).^{[1] [2]}

See Also

• Glyoxalase 3D structures

References

1. ↑ O'Young J, Sukdeo N, Honek JF. Escherichia coli glyoxalase II is a binuclear zinc-dependent metalloenzyme. Arch Biochem Biophys. 2007 Mar 1;459(1):20-6. PMID:17196158 doi:10.1016/j.abb.2006.11.024
2. ↑ Reiger M, Lassak J, Jung K. Deciphering the role of the type II glyoxalase isoenzyme YcbL (GlxII-2) in Escherichia coli. FEMS Microbiol Lett. 2015 Jan;362(2):1-7. PMID:25670698 doi:10.1093/femsle/fnu014