6s9f
From Proteopedia
Drosophila OTK, extracellular domains 3-5
Structural highlights
FunctionPTK7_DROME Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons.[1] [2] [3] Publication Abstract from PubMedThe transmembrane protein OTK plays an essential role in plexin and Wnt signaling during Drosophila development. We have determined a crystal structure of the last three domains of the OTK ectodomain and found that OTK shows high conformational flexibility resulting from mobility at the interdomain interfaces. We failed to detect direct binding between Drosophila Plexin A (PlexA) and OTK, which was suggested previously. We found that, instead of PlexA, OTK directly binds semaphorin 1a. Our binding analyses further revealed that glycosaminoglycans, heparin and heparan sulfate, are ligands for OTK and thus may play a role in the Sema1a-PlexA axon guidance system. Drosophila OTK Is a Glycosaminoglycan-Binding Protein with High Conformational Flexibility.,Rozbesky D, Monistrol J, Jain V, Hillier J, Padilla-Parra S, Jones EY Structure. 2020 Mar 13. pii: S0969-2126(20)30072-1. doi:, 10.1016/j.str.2020.02.008. PMID:32187531[4] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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