Structural highlights
Function
ZCHC4_HUMAN rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA (PubMed:30531910). N6-methylation of adenine(4220) in 28S rRNA is required for translation (PubMed:30531910).[1]
References
- ↑ Ma H, Wang X, Cai J, Dai Q, Natchiar SK, Lv R, Chen K, Lu Z, Chen H, Shi YG, Lan F, Fan J, Klaholz BP, Pan T, Shi Y, He C. N(6-)Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation. Nat Chem Biol. 2019 Jan;15(1):88-94. doi: 10.1038/s41589-018-0184-3. Epub 2018, Dec 10. PMID:30531910 doi:http://dx.doi.org/10.1038/s41589-018-0184-3