| Structural highlights
Function
SFH5_YEAST Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses (PubMed:32780017).[1] [2] [3] [4]
References
- ↑ Li X, Routt SM, Xie Z, Cui X, Fang M, Kearns MA, Bard M, Kirsch DR, Bankaitis VA. Identification of a novel family of nonclassic yeast phosphatidylinositol transfer proteins whose function modulates phospholipase D activity and Sec14p-independent cell growth. Mol Biol Cell. 2000 Jun;11(6):1989-2005. PMID:10848624
- ↑ Schnabl M, Oskolkova OV, Holic R, Brezna B, Pichler H, Zagorsek M, Kohlwein SD, Paltauf F, Daum G, Griac P. Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover. Eur J Biochem. 2003 Aug;270(15):3133-45. PMID:12869188
- ↑ Mousley CJ, Tyeryar KR, Ryan MM, Bankaitis VA. Sec14p-like proteins regulate phosphoinositide homoeostasis and intracellular protein and lipid trafficking in yeast. Biochem Soc Trans. 2006 Jun;34(Pt 3):346-50. PMID:16709158 doi:10.1042/BST0340346
- ↑ Khan D, Lee D, Gulten G, Aggarwal A, Wofford J, Krieger I, Tripathi A, Patrick JW, Eckert DM, Laganowsky A, Sacchettini J, Lindahl P, Bankaitis VA. A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins. Elife. 2020 Aug 11;9:e57081. PMID:32780017 doi:10.7554/eLife.57081
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