6w8r

Structural highlights

Function

MCA4_ARATH Cysteine protease that cleaves specifically after arginine or lysine residues. Does not cleave caspase-specific substrates. Plays a positive regulatory role in biotic and abiotic stress-induced programmed cell death.^{[1] [2] [3]}

References

1. ↑ Vercammen D, van de Cotte B, De Jaeger G, Eeckhout D, Casteels P, Vandepoele K, Vandenberghe I, Van Beeumen J, Inzé D, Van Breusegem F. Type II metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana cleave substrates after arginine and lysine. J Biol Chem. 2004 Oct 29;279(44):45329-36. PMID:15326173 doi:10.1074/jbc.M406329200
2. ↑ Watanabe N, Lam E. Calcium-dependent activation and autolysis of Arabidopsis metacaspase 2d. J Biol Chem. 2011 Mar 25;286(12):10027-40. PMID:21209078 doi:10.1074/jbc.M110.194340
3. ↑ Watanabe N, Lam E. Arabidopsis metacaspase 2d is a positive mediator of cell death induced during biotic and abiotic stresses. Plant J. 2011 Jun;66(6):969-82. PMID:21395887 doi:10.1111/j.1365-313X.2011.04554.x