6y2s

Structural highlights

Function

RNLA_ECOLI Toxic component of a toxin-antitoxin (TA) module. A stable (half-life 27.6 minutes) endoribonuclease that in the absence of cognate antitoxin RnlB causes generalized RNA degradation. Degrades late enterobacteria phage T4 mRNAs, protecting the host against T4 reproduction. Activity is inhibited by cognate antitoxin RnlB and by enterobacteria phage T4 protein Dmd. Targets cyaA mRNA.^{[1] [2] [3] [4]}

References

1. ↑ Otsuka Y, Koga M, Iwamoto A, Yonesaki T. A role of RnlA in the RNase LS activity from Escherichia coli. Genes Genet Syst. 2007 Aug;82(4):291-9. PMID:17895580
2. ↑ Iwamoto A, Lemire S, Yonesaki T. Post-transcriptional control of Crp-cAMP by RNase LS in Escherichia coli. Mol Microbiol. 2008 Dec;70(6):1570-8. doi: 10.1111/j.1365-2958.2008.06504.x. Epub, 2008 Oct 23. PMID:19019153 doi:http://dx.doi.org/10.1111/j.1365-2958.2008.06504.x
3. ↑ Koga M, Otsuka Y, Lemire S, Yonesaki T. Escherichia coli rnlA and rnlB compose a novel toxin-antitoxin system. Genetics. 2011 Jan;187(1):123-30. doi: 10.1534/genetics.110.121798. Epub 2010 Oct, 26. PMID:20980243 doi:http://dx.doi.org/10.1534/genetics.110.121798
4. ↑ Otsuka Y, Yonesaki T. Dmd of bacteriophage T4 functions as an antitoxin against Escherichia coli LsoA and RnlA toxins. Mol Microbiol. 2012 Feb;83(4):669-81. PMID:22403819