Structural highlights
Function
POLR_TYMV Acts as a cysteine protease, methyltransferase and deubiquitinase. The cyteine protease activity cleaves the polyprotein giving rise to mature proteins. The methyltransferase domain is probably involved in viral RNA capping. The deubiquitylating activity counteracts the degradation of the viral polymerase mediated by the host ubiquitin-proteasome system. The polymerase is thus stabilized and infectivity is increased.[1] RNA-directed RNA polymerase is responsible for the replication and transcription of the genome.[2]
See Also
References
- ↑ Chenon M, Camborde L, Cheminant S, Jupin I. A viral deubiquitylating enzyme targets viral RNA-dependent RNA polymerase and affects viral infectivity. EMBO J. 2012 Feb 1;31(3):741-53. doi: 10.1038/emboj.2011.424. Epub 2011 Nov 25. PMID:22117220 doi:http://dx.doi.org/10.1038/emboj.2011.424
- ↑ Chenon M, Camborde L, Cheminant S, Jupin I. A viral deubiquitylating enzyme targets viral RNA-dependent RNA polymerase and affects viral infectivity. EMBO J. 2012 Feb 1;31(3):741-53. doi: 10.1038/emboj.2011.424. Epub 2011 Nov 25. PMID:22117220 doi:http://dx.doi.org/10.1038/emboj.2011.424
