7b2r

Structural highlights

Disease

TRIM2_HUMAN Charcot-Marie-Tooth disease type 2R. The disease is caused by variants affecting the gene represented in this entry.

Function

TRIM2_HUMAN UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.[UniProtKB:Q9ESN6]