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7br9
From Proteopedia
Crystal structure of mus musculus IRG1
Structural highlights
FunctionIRG1_MOUSE Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response (PubMed:23609450, PubMed:23610393, PubMed:30635240, PubMed:31548418). Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages (PubMed:23609450). Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB (PubMed:23610393, PubMed:35662396). Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (PubMed:30635240). Plays a role in the embryo implantation (PubMed:14500577).[1] [2] [3] [4] [5] [6] Publication Abstract from PubMedPROTEIN DATA BANK ACCESSION CODES: Coordinate and structural factors were deposited with the Protein Data Bank under PDB ID: 7BR9. The crystal structure of mouse IRG1 suggests that cis-aconitate decarboxylase has an open and closed conformation.,Chun HL, Lee SY, Kim KH, Lee CS, Oh TJ, Park HH PLoS One. 2020 Dec 1;15(12):e0242383. doi: 10.1371/journal.pone.0242383., eCollection 2020. PMID:33259501[7] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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