7c1z

Structural highlights

Function

PUKI_ARATH Catalyzes the phosphorylation of pseudouridine to pseudouridine 5'-phosphate (PsiMP) (PubMed:31907295). Catalyzes the first step in a pseudouridine degradation pathway (PubMed:31907295). Acts together with the pseudouridine 5'-phosphate glycosidase PUMY in the peroxisome to prevent toxic pseudouridine monophosphate accumulation (PubMed:31907295).^[1]

References

1. ↑ Chen M, Witte CP. A Kinase and a Glycosylase Catabolize Pseudouridine in the Peroxisome to Prevent Toxic Pseudouridine Monophosphate Accumulation. Plant Cell. 2020 Mar;32(3):722-739. PMID:31907295 doi:10.1105/tpc.19.00639