Structural highlights
Publication Abstract from PubMed
G-quadruplex (G4) DNA structures with a left-handed backbone progression have unique and conserved structural features. Studies on sequence dependency of the structures revealed the prerequisites and some minimal motifs required for left-handed G4 formation. To extend the boundaries, we explore the adaptability of left-handed G4s towards the existence of bulges. Here we present two X-ray crystal structures and an NMR solution structure of left-handed G4s accommodating one, two and three bulges. Bulges in left-handed G4s show distinct characteristics as compared to those in right-handed G4s. The elucidation of intricate structural details will help in understanding the possible roles and limitations of these unique structures.
Bulges in left-handed G-quadruplexes.,Das P, Ngo KH, Winnerdy FR, Maity A, Bakalar B, Mechulam Y, Schmitt E, Phan AT Nucleic Acids Res. 2021 Jan 27. pii: 6121459. doi: 10.1093/nar/gkaa1259. PMID:33503265[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Das P, Ngo KH, Winnerdy FR, Maity A, Bakalar B, Mechulam Y, Schmitt E, Phan AT. Bulges in left-handed G-quadruplexes. Nucleic Acids Res. 2021 Jan 27. pii: 6121459. doi: 10.1093/nar/gkaa1259. PMID:33503265 doi:http://dx.doi.org/10.1093/nar/gkaa1259
