Structural highlights
Function
KDHC_PAENI Molybdo-flavoprotein enzyme complex involved in nicotine degradation. The subunit gamma (large subunit) contains the substrate-binding sites, the subunit alpha (medium subunit) binds FAD and the subunit beta (small subunit) has a 2Fe-2S ferredoxin-type domain which binds 2 2Fe-2S clusters.[1] [2]
References
- ↑ Sachelaru P, Schiltz E, Brandsch R. A functional mobA gene for molybdopterin cytosine dinucleotide cofactor biosynthesis is required for activity and holoenzyme assembly of the heterotrimeric nicotine dehydrogenases of Arthrobacter nicotinovorans. Appl Environ Microbiol. 2006 Jul;72(7):5126-31. PMID:16820521 doi:10.1128/AEM.00437-06
- ↑ Schenk S, Hoelz A, Krauss B, Decker K. Gene structures and properties of enzymes of the plasmid-encoded nicotine catabolism of Arthrobacter nicotinovorans. J Mol Biol. 1998 Dec 18;284(5):1323-39. PMID:9878353 doi:10.1006/jmbi.1998.2227
