| Structural highlights
Function
PYRI4_STRRG Involved in the biosynthesis of the spirotetramate antibiotics pyrroindomycins. Catalyzes the intramolecular cyclization forming the spiro-conjugate moiety in pyrroindomycins, via an exo-selective [4+2] cycloaddition reaction.[1] [2]
References
- ↑ Tian Z, Sun P, Yan Y, Wu Z, Zheng Q, Zhou S, Zhang H, Yu F, Jia X, Chen D, Mándi A, Kurtán T, Liu W. An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins. Nat Chem Biol. 2015 Apr;11(4):259-65. PMID:25730548 doi:10.1038/nchembio.1769
- ↑ Zheng Q, Guo Y, Yang L, Zhao Z, Wu Z, Zhang H, Liu J, Cheng X, Wu J, Yang H, Jiang H, Pan L, Liu W. Enzyme-Dependent [4 + 2] Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4. Cell Chem Biol. 2016 Feb 8. pii: S2451-9456(16)30006-X. doi:, 10.1016/j.chembiol.2016.01.005. PMID:26877021 doi:http://dx.doi.org/10.1016/j.chembiol.2016.01.005
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