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Structural highlights

Function

MBD5_ARATH Transcriptional regulator that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. In addition, binds specifically methylated m(5)CpNpN but not m(5)CpNpG (N is A, T or C). Plays probably a role in gene silencing.^{[1] [2] [3]}

See Also

• Methyl CpG binding protein 3D structures

References

1. ↑ Zemach A, Grafi G. Characterization of Arabidopsis thaliana methyl-CpG-binding domain (MBD) proteins. Plant J. 2003 Jun;34(5):565-72. doi: 10.1046/j.1365-313x.2003.01756.x. PMID:12787239 doi:http://dx.doi.org/10.1046/j.1365-313x.2003.01756.x
2. ↑ Ito M, Koike A, Koizumi N, Sano H. Methylated DNA-binding proteins from Arabidopsis. Plant Physiol. 2003 Dec;133(4):1747-54. doi: 10.1104/pp.103.026708. Epub 2003 Nov, 6. PMID:14605234 doi:http://dx.doi.org/10.1104/pp.103.026708
3. ↑ Scebba F, Bernacchia G, De Bastiani M, Evangelista M, Cantoni RM, Cella R, Locci MT, Pitto L. Arabidopsis MBD proteins show different binding specificities and nuclear localization. Plant Mol Biol. 2003 Nov;53(5):715-31. doi: 10.1023/B:PLAN.0000019118.56822.a9. PMID:15010609 doi:http://dx.doi.org/10.1023/B:PLAN.0000019118.56822.a9