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Publication Abstract from PubMed

Interaction analysis between small molecules and RNA as well as structure determination of RNA-small molecule complexes will be the clues to search for compounds that bind to specific mRNA or non-coding RNA in drug discovery. In this study, the RNA binding ability of a fluoroquinolone derivative, KG022, was examined against single-residue bulge-containing hairpin RNAs as RNA models. NMR analysis indicated that KG022 interacts with the RNAs in the vicinity of the bulge residue, with preferring C and G as the bulge residues. The solution structures of the RNA-KG022 complexes showed that the KG022 binds to the RNAs at the bulge-out regions. Each substituent in KG022 interacts specific position of RNAs around the bulge-out region probably contributing the specificity of the binding. This work provides a novel member for the RNA-targeted small molecules.

Interaction between a fluoroquinolone derivative and RNAs with a single bulge.,Nagano K, Kamimura T, Kawai G J Biochem. 2021 Nov 16. pii: 6429710. doi: 10.1093/jb/mvab124. PMID:34791286^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.