Structural highlights
Function
REP68_AAV2S Plays an essential role in the initiation of viral DNA synthesis. Binds specifically to an inverted terminal repeat element (ITR) on the 3' and 5' ends of the viral DNA, where it cleaves a site specifically to generate a priming site for initiation of the synthesis of a complementary strand. Plays also a role as transcriptional regulator, DNA helicase and as key factor in site-specific integration of the viral genome. Inhibits the host cell cycle G1/S and G2/M transitions. These arrests may provide essential cellular factors for viral DNA replication.[1]
References
- ↑ Zhou X, Zolotukhin I, Im DS, Muzyczka N. Biochemical characterization of adeno-associated virus rep68 DNA helicase and ATPase activities. J Virol. 1999 Feb;73(2):1580-90. PMID:9882364
