7jw6

Structural highlights

Function

MUT7_DROME Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs, in particular multiple-isoform miRNAs, which represents a critical step in miRNA maturation.^{[1] [2]}

References

1. ↑ Liu N, Abe M, Sabin LR, Hendriks GJ, Naqvi AS, Yu Z, Cherry S, Bonini NM. The exoribonuclease Nibbler controls 3' end processing of microRNAs in Drosophila. Curr Biol. 2011 Nov 22;21(22):1888-93. PMID:22055292 doi:10.1016/j.cub.2011.10.006
2. ↑ Han BW, Hung JH, Weng Z, Zamore PD, Ameres SL. The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1. Curr Biol. 2011 Nov 22;21(22):1878-87. PMID:22055293 doi:10.1016/j.cub.2011.09.034