7jxg

Structural highlights

Function

MTND_HUMAN Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.[HAMAP-Rule:MF_03154]^{[1] [2]}

See Also

• Dioxygenase 3D structures

References

1. ↑ Yeh CT, Lai HY, Chen TC, Chu CM, Liaw YF. Identification of a hepatic factor capable of supporting hepatitis C virus replication in a nonpermissive cell line. J Virol. 2001 Nov;75(22):11017-24. PMID:11602742 doi:http://dx.doi.org/10.1128/JVI.75.22.11017-11024.2001
2. ↑ Hirano W, Gotoh I, Uekita T, Seiki M. Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway. Genes Cells. 2005 Jun;10(6):565-74. PMID:15938715 doi:http://dx.doi.org/10.1111/j.1365-2443.2005.00859.x