7lft

Structural highlights

Disease

CNGA1_HUMAN Retinitis pigmentosa. The disease is caused by variants affecting the gene represented in this entry.

Function

CNGA1_HUMAN Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.[UniProtKB:Q00194]

See Also

• Ion channels 3D structures