7lhr

Structural highlights

Function

CYSH_MYCTU Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.[HAMAP-Rule:MF_00063]^{[1] [2] [3]}

References

1. ↑ Williams SJ, Senaratne RH, Mougous JD, Riley LW, Bertozzi CR. 5'-adenosinephosphosulfate lies at a metabolic branch point in mycobacteria. J Biol Chem. 2002 Sep 6;277(36):32606-15. PMID:12072441 doi:10.1074/jbc.M204613200
2. ↑ Hong JA, Bhave DP, Carroll KS. Identification of critical ligand binding determinants in Mycobacterium tuberculosis adenosine-5'-phosphosulfate reductase. J Med Chem. 2009 Sep 10;52(17):5485-95. PMID:19678707 doi:10.1021/jm900728u
3. ↑ Paritala H, Carroll KS. A continuous spectrophotometric assay for adenosine 5'-phosphosulfate reductase activity with sulfite-selective probes. Anal Biochem. 2013 Sep 1;440(1):32-9. PMID:23711725 doi:10.1016/j.ab.2013.05.007