Structural highlights
Publication Abstract from PubMed
Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hbeta-Halpha and Hdelta-Hgamma from Marseillevirus are structurally analogous to the eukaryotic histone pairs H2B-H2A and H4-H3. These viral histones form 'forced' heterodimers, and a heterotetramer of four such heterodimers assembles DNA to form structures virtually identical to canonical eukaryotic nucleosomes.
The structure of a virus-encoded nucleosome.,Valencia-Sanchez MI, Abini-Agbomson S, Wang M, Lee R, Vasilyev N, Zhang J, De Ioannes P, La Scola B, Talbert P, Henikoff S, Nudler E, Erives A, Armache KJ Nat Struct Mol Biol. 2021 May;28(5):413-417. doi: 10.1038/s41594-021-00585-7. , Epub 2021 Apr 29. PMID:33927388[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Valencia-Sánchez MI, Abini-Agbomson S, Wang M, Lee R, Vasilyev N, Zhang J, De Ioannes P, La Scola B, Talbert P, Henikoff S, Nudler E, Erives A, Armache KJ. The structure of a virus-encoded nucleosome. Nat Struct Mol Biol. 2021 May;28(5):413-417. PMID:33927388 doi:10.1038/s41594-021-00585-7
