Structural highlights
Function
EXO5_HUMAN Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity.[1]
See Also
References
- ↑ Sparks JL, Kumar R, Singh M, Wold MS, Pandita TK, Burgers PM. Human exonuclease 5 is a novel sliding exonuclease required for genome stability. J Biol Chem. 2012 Dec 14;287(51):42773-83. doi: 10.1074/jbc.M112.422444. Epub, 2012 Oct 24. PMID:23095756 doi:http://dx.doi.org/10.1074/jbc.M112.422444
