Structural highlights
Function
DCTP1_HUMAN Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.[1]
References
- ↑ Requena CE, Pérez-Moreno G, Ruiz-Pérez LM, Vidal AE, González-Pacanowska D. The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells. Biochem J. 2014 Apr 1;459(1):171-80. PMID:24467396 doi:10.1042/BJ20130894
