7o1h
From Proteopedia
Hybrid-2R quadruplex-duplex with (-p-p-l) topology and 3 syn residues
Structural highlights
Publication Abstract from PubMedCanonical G-quadruplexes can adopt a variety of different topologies depending on the arrangement of propeller, lateral, or diagonal loops connecting the four G-columns. A novel intramolecular G-quadruplex structure is derived through inversion of the last G-tract of a three-layered parallel fold, associated with the transition of a single propeller into a lateral loop. The resulting (3+1) hybrid fold features three syn.anti.anti.anti G-tetrads with a 3'-terminal all- syn G-column. Although the ability of forming a duplex stem-loop between G-tracts seems beneficial for a propeller-to-lateral loop rearrangement, unmodified G-rich sequences resist folding into the new (3+1) topology. However, refolding can be driven by the incorporation of syn -favoring guanosine analogs into positions of the fourth G-stretch. The presented hybrid-type G-quadruplex structure as determined by NMR may provide for an additional scaffold in quadruplex-based technologies. Expanding the Topological Landscape by a G-Column Flip of a Parallel G-Quadruplex.,Mohr S, Jana J, Vianney YM, Weisz K Chemistry. 2021 May 6. doi: 10.1002/chem.202101181. PMID:33955615[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
| ||||||||||||||||||||
