| Structural highlights
Function
ACYLT_MYCS2 Catalyzes the acylation to the position 6 of the alpha-1,2-linked mannose residue of the phosphatidyl-myo-inositol dimannoside (PIM2) or monomannoside (PIM1).[1]
Publication Abstract from PubMed
[Figure: see text].
Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA.,Anso I, Basso LGM, Wang L, Marina A, Paez-Perez ED, Jager C, Gavotto F, Tersa M, Perrone S, Contreras FX, Prandi J, Gilleron M, Linster CL, Corzana F, Lowary TL, Trastoy B, Guerin ME Sci Adv. 2021 Oct 15;7(42):eabj4565. doi: 10.1126/sciadv.abj4565. Epub 2021 Oct, 15. PMID:34652941[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Kordulakova J, Gilleron M, Puzo G, Brennan PJ, Gicquel B, Mikusova K, Jackson M. Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium species. J Biol Chem. 2003 Sep 19;278(38):36285-95. Epub 2003 Jul 8. PMID:12851411 doi:http://dx.doi.org/10.1074/jbc.M303639200
- ↑ Anso I, Basso LGM, Wang L, Marina A, Paez-Perez ED, Jager C, Gavotto F, Tersa M, Perrone S, Contreras FX, Prandi J, Gilleron M, Linster CL, Corzana F, Lowary TL, Trastoy B, Guerin ME. Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA. Sci Adv. 2021 Oct 15;7(42):eabj4565. doi: 10.1126/sciadv.abj4565. Epub 2021 Oct, 15. PMID:34652941 doi:http://dx.doi.org/10.1126/sciadv.abj4565
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