7oqs

Structural highlights

Function

AMOT_HUMAN Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.^{[1] [2]}

See Also

• 14-3-3 protein 3D structures

References

1. ↑ Troyanovsky B, Levchenko T, Mansson G, Matvijenko O, Holmgren L. Angiomotin: an angiostatin binding protein that regulates endothelial cell migration and tube formation. J Cell Biol. 2001 Mar 19;152(6):1247-54. PMID:11257124
2. ↑ Wells CD, Fawcett JP, Traweger A, Yamanaka Y, Goudreault M, Elder K, Kulkarni S, Gish G, Virag C, Lim C, Colwill K, Starostine A, Metalnikov P, Pawson T. A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Cell. 2006 May 5;125(3):535-48. doi: 10.1016/j.cell.2006.02.045. PMID:16678097 doi:http://dx.doi.org/10.1016/j.cell.2006.02.045