7p41
From Proteopedia
Crystal Structure of human mARC1 A165T Variant
Structural highlights
FunctionD9IEF7_BPT4 MARC1_HUMAN As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively.[1] Publication Abstract from PubMedA study recently published in Hepatology Communications provided insights into a variant of MTARC1 protein, which conveys protection against liver disease. Here, we report a crystal structure of the variant protein at near-atomic resolution and compare it to the structure of the wildtype protein. Letter to the editor: The clinically relevant MTARC1 p.Ala165Thr variant impacts neither the fold nor active site architecture of the human mARC1 protein.,Struwe MA, Clement B, Scheidig A Hepatol Commun. 2022 May 13. doi: 10.1002/hep4.1984. PMID:35560545[2] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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