Structural highlights
Function
PABB_BACSU Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC.[1]
References
- ↑ Schadt HS, Schadt S, Oldach F, Sussmuth RD. 2-Amino-2-deoxyisochorismate is a key intermediate in Bacillus subtilis p-aminobenzoic acid biosynthesis. J Am Chem Soc. 2009 Mar 18;131(10):3481-3. doi: 10.1021/ja809283u. PMID:19275258 doi:http://dx.doi.org/10.1021/ja809283u
