7qp5

Structural highlights

Function

FHUF_ECOLI Siderophore-iron reductase which is involved in iron removal from the hydroxamate-type siderophores coprogen, ferrichrome and ferrioxamine B after their transport into the cell (PubMed:14756576). Binds both the iron-loaded and the apo forms of ferrichrome (PubMed:33559753).^{[1] [2]}

References

1. ↑ Matzanke BF, Anemüller S, Schünemann V, Trautwein AX, Hantke K. FhuF, part of a siderophore-reductase system. Biochemistry. 2004 Feb 10;43(5):1386-92. PMID:14756576 doi:10.1021/bi0357661
2. ↑ Trindade IB, Hernandez G, Lebègue E, Barrière F, Cordeiro T, Piccioli M, Louro RO. Conjuring up a ghost: structural and functional characterization of FhuF, a ferric siderophore reductase from E. coli. J Biol Inorg Chem. 2021 May;26(2-3):313-326. PMID:33559753 doi:10.1007/s00775-021-01854-y