7qu8

Structural highlights

Function

AGRG3_HUMAN Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins (PubMed:22575658).[UniProtKB:Q8R0T6]^{[1] [2]}

References

1. ↑ Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X. Signaling property study of adhesion G-protein-coupled receptors. FEBS Lett. 2012 Apr 24;586(8):1214-9. doi: 10.1016/j.febslet.2012.03.014. Epub, 2012 Mar 21. PMID:22575658 doi:http://dx.doi.org/10.1016/j.febslet.2012.03.014
2. ↑ Valtcheva N, Primorac A, Jurisic G, Hollmen M, Detmar M. The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42. J Biol Chem. 2013 Dec 13;288(50):35736-48. doi: 10.1074/jbc.M113.512954. Epub, 2013 Oct 31. PMID:24178298 doi:http://dx.doi.org/10.1074/jbc.M113.512954